Proteomics of acute myeloid leukaemia: cytogenetic risk groups differ specifically in their proteome, interactome and post-translational protein modifications
نویسندگان
چکیده
منابع مشابه
Post-Translational Modifications Mapping Protein Networks Disease Proteomics
Protein post-translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTMs and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of ...
متن کاملProteomics studies of post-translational modifications in plants.
Post-translational modifications of proteins greatly increase protein complexity and dynamics, co-ordinating the intricate regulation of biological events. The global identification of post-translational modifications is a difficult task that is currently accelerated by advances in proteomics techniques. There has been significant development in sample preparation methods and mass spectrometry ...
متن کاملThe clinical significance of cytogenetic abnormalities in acute myeloid leukaemia.
During the last three decades it has become apparent that the majority of cases of acute myeloid leukaemia (AML) are characterized by at least one of a variety of recurrent chromosomal abnormalities. These changes have been found in many instances to correlate closely with distinct morphological features and clinical characteristics, the molecular basis of which is becoming increasingly underst...
متن کاملCytogenetic study in acute myeloid leukaemia using peripheral blood samples sent by post.
The patterns of chromosomal abnormalities in acute myeloid leukaemia (AML) revealed by study of peripheral blood specimens (group A) up to seven days old were comparable to the results from fresh bone marrow (group B). However, a decreasing proportion of cases providing enough metaphases for study, an increasing proportion of cases with chromosomal abnormalities, a decreasing ratio AN:AN + AA (...
متن کاملPost-translational modifications of protein biopharmaceuticals.
The majority of therapeutic proteins display one or more post-translational modifications (PTMs). These modifications normally influence the biochemical and therapeutic properties of such proteins. Choosing an expression system capable of generating an appropriate product PTM profile remains one of the most crucial decisions a drug developer must make. This review considers the PTMs most often ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncogene
سال: 2006
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1209689